De Leon F D, Odom J, Hudkins P, Vijayakumar R, Heine M W
J Reprod Med. 1986 Nov;31(11):1014-6.
Adhesion formation was examined in 45 rats that were divided into five groups of 9 animals each: control, oral ibuprofen, intramuscular ibuprofen, intraperitoneal 32% dextran 70, and oral ibuprofen plus intraperitoneal 32% dextran 70. Four weeks after receiving a standard injury, all the animals were killed and the adhesions scored blindly. Both the oral and intramuscular ibuprofen groups had significantly less severe adhesion formation (P less than .01) when compared to the control group. Although 32% dextran 70 alone showed no beneficial effect in reducing adhesions, the combination of oral ibuprofen and 32% dextran 70 had the least adhesion formation (P less than .002) when compared to the control group. Oral and intramuscular ibuprofen seem to be equally efficient in reducing postoperative adhesions. Furthermore, the combination of oral ibuprofen and 32% dextran 70 appears to have a synergistic effect.
在45只大鼠中检测粘连形成情况，这些大鼠被分为五组，每组9只动物：对照组、口服布洛芬组、肌肉注射布洛芬组、腹腔注射32%右旋糖酐70组以及口服布洛芬加腹腔注射32%右旋糖酐70组。在接受标准损伤四周后，所有动物均被处死，并对粘连情况进行盲法评分。与对照组相比，口服和肌肉注射布洛芬组的粘连形成严重程度均显著降低（P小于0.01）。虽然单独使用32%右旋糖酐70在减少粘连方面未显示出有益效果，但与对照组相比，口服布洛芬与32%右旋糖酐70联合使用时粘连形成最少（P小于0.002）。口服和肌肉注射布洛芬在减少术后粘连方面似乎同样有效。此外，口服布洛芬与32%右旋糖酐70联合使用似乎具有协同作用。
