Pittman M
Dev Biol Stand. 1980;45:129-35.
Mice from 14 suppliers (breeders) responded significantly different in the mouse-weight-gain test for toxicity of pertussis vaccine. Seven-day weight gain varied by 2.4 fold (2.5 to 6.1 g) and did not correlate with normal gain. Weight gain expressed as percentage-weight gain of the control varied by two-fold (52 to 104%). The percentage-weight gain requirement of greater than 60% (The Netherlands) was more discriminatory between mouse breeds than was the requirement of greate than or equal to 3.0 g gain (U.S.A.). Percentage-weight gains greater than 60%, however, showed significant distinctions. Specifications for the mice for this test are needed. Suggestions for the selection of the mouse are given.
来自14个供应商（种鼠繁育者）的小鼠在百日咳疫苗毒性的小鼠体重增加试验中反应显著不同。7天体重增加量相差2.4倍（2.5至6.1克），且与正常增加量无关。以对照组体重增加百分比表示的体重增加量相差两倍（52%至104%）。大于60%（荷兰）的体重增加百分比要求在不同小鼠品种间比大于或等于3.0克增加量（美国）的要求更具区分性。然而，大于60%的体重增加百分比显示出显著差异。需要为此试验制定小鼠的规格标准。给出了小鼠选择的建议。
