Riddlesberger M M, Lebenthal E
Gastroenterology. 1980 Aug;79(2):265-70.
The small colonic mucosal nodules that have been referred to in the past as lymphatic nodular hyperplasia are felt to represent a normal response of the prominent colonic lymphatic tissue in children. To support this hypothesis, a prospective study of all air-contrast barium enemas, colonoscopies, and intestinal biopsies performed during 1 yr was carried out. During that year 48 patients had air-contrast barium enemas, and 21 of these 48 patients also had colonoscopy and mucosal biopsies. Greater than half of the children studied by air-contrast barium enema (26 out of 48) and colonoscopy (12 out of 21) had nodular colonic mucosa. These nodules were described at colonoscopy as being smooth surfaced, yellowish-white, 1-2 mm in diameter. There was no correlation between the presence or absence of these nodules with any symptom or symptom complex. The younger patients, the more frequently these nodules were oberved. No immunologic disorder was associated with the nodular colonic mucosa in the children that were tested. Nodular colonic mucosa in childhood should be considered a frequent finding indicative of normal lymphatic response to nonspecific stimuli, which may often be infectious in nature.
过去被称为淋巴小结节增生的结肠小黏膜结节，被认为是儿童结肠突出淋巴组织的一种正常反应。为支持这一假说，对1年内进行的所有气钡双重造影灌肠、结肠镜检查及肠道活检进行了一项前瞻性研究。在那一年，48例患者进行了气钡双重造影灌肠，其中21例患者还进行了结肠镜检查和黏膜活检。通过气钡双重造影灌肠研究的儿童中超过一半（48例中的26例）以及通过结肠镜检查的儿童中超过一半（21例中的12例）有结肠黏膜结节。这些结节在结肠镜检查中被描述为表面光滑、黄白色、直径1 - 2毫米。这些结节的有无与任何症状或症状组合之间均无关联。患者年龄越小，观察到这些结节的频率越高。在接受检测的儿童中，结节状结肠黏膜与免疫紊乱无关。儿童期结节状结肠黏膜应被视为一种常见表现，表明对非特异性刺激的正常淋巴反应，这种刺激在性质上通常可能是感染性的。
