给予磷酸泼尼松龙21作为保留灌肠剂后血浆泼尼松龙水平和肾上腺皮质反应性。
Plasma prednisolone levels and adrenocortical responsiveness after administration of prednisolone-21-phosphate as a retention enema.
作者信息
Lee D A, Taylor G M, James V H, Walker G
出版信息
Gut. 1979 May;20(5):349-55. doi: 10.1136/gut.20.5.349.
Abstract
Plasma prednisolone levels have been measured by radioimmunoassay after oral and rectal administration to healthy volunteers and to patients with idiopathic proctocolitis. The amount of prednisolone absorbed from a 20 mg retention enema given to patients with proctocolitis was about 44% of that absorbed from the same dose orally administered. Adrenocortical response to synthetic ACTH in patients receiving prolonged rectal therapy was either normal, or only slightly impaired, and this may be related to the pattern of steroid absorption rather than to the total amount absorbed.
摘要
已通过放射免疫分析法测定了健康志愿者和特发性直肠结肠炎患者口服及直肠给药后的血浆泼尼松龙水平。给予直肠结肠炎患者20mg保留灌肠剂后，泼尼松龙的吸收量约为口服相同剂量后吸收量的44%。接受长期直肠治疗的患者对合成促肾上腺皮质激素的肾上腺皮质反应正常，或仅略有受损，这可能与类固醇的吸收方式有关，而非与吸收总量有关。
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