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1
Plasma prednisolone levels and adrenocortical responsiveness after administration of prednisolone-21-phosphate as a retention enema.给予磷酸泼尼松龙21作为保留灌肠剂后血浆泼尼松龙水平和肾上腺皮质反应性。
Gut. 1979 May;20(5):349-55. doi: 10.1136/gut.20.5.349.
2
Rectally administered prednisolone--evidence for a predominantly local action.直肠给药的泼尼松龙——主要为局部作用的证据。
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3
Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.在结肠炎患者中，以磷酸泼尼松龙21-磷酸酯作为保留灌肠剂给药后血浆泼尼松龙水平。
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Betamethasone 17-valerate and prednisolone 21-phosphate retention enemata in proctocolitis. A multicentre trial.倍他米松17-戊酸酯和泼尼松龙21-磷酸酯保留灌肠剂治疗直肠结肠炎。一项多中心试验。
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Gut. 1985 Aug;26(8):822-4. doi: 10.1136/gut.26.8.822.
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[A clinical study on the effect of extrinsic corticotropin on the pituitary-adrenocortical function (author's transl)].
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Rectally administered prednisolone--evidence for a predominantly local action.直肠给药的泼尼松龙——主要为局部作用的证据。
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Treatment of distal ulcerative colitis (proctosigmoiditis) in relapse: comparison of hydrocortisone enemas and rectal hydrocortisone foam.复发期远端溃疡性结肠炎（直肠乙状结肠炎）的治疗：氢化可的松灌肠剂与直肠用氢化可的松泡沫剂的比较
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Topical administration of 5-aminosalicylic acid enemas in patients with ulcerative colitis. Studies on rectal absorption and excretion.溃疡性结肠炎患者局部应用5-氨基水杨酸灌肠剂。直肠吸收与排泄的研究。
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Radiation-induced proctosigmoiditis. Prospective, randomized, double-blind controlled trial of oral sulfasalazine plus rectal steroids versus rectal sucralfate.放射性直肠乙状结肠炎。口服柳氮磺胺吡啶加直肠用类固醇与直肠用硫糖铝的前瞻性、随机、双盲对照试验。
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Double blind, controlled trial of 4-aminosalicylic acid and prednisolone enemas in distal ulcerative colitis.4-氨基水杨酸与泼尼松龙灌肠剂治疗远端溃疡性结肠炎的双盲对照试验
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本文引用的文献

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Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.放射性6-α-甲基泼尼松龙在溃疡性结肠炎中的直肠吸收情况。
J Med Liban. 1961;14:380-6.
2
A RAPID TEST OF ADRENOCORTICAL FUNCTION.肾上腺皮质功能的快速检测
Lancet. 1965 Jan 30;1(7379):243-5. doi: 10.1016/s0140-6736(65)91526-6.
3
URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.溃疡性结肠炎直肠内治疗后泼尼松龙的尿排泄情况
Br Med J. 1964 Oct 24;2(5416):1045-6. doi: 10.1136/bmj.2.5416.1045.
4
VARIATION BETWEEN OBSERVERS IN DESCRIBING MUCOSAL APPEARANCES IN PROCTOCOLITIS.观察者在描述直肠炎黏膜外观时的差异。
Br Med J. 1964 Jan 11;1(5375):89-92. doi: 10.1136/bmj.1.5375.89.
5
Adrenal cortical and pituitary function after intrarectal steroid therapy.直肠内类固醇治疗后的肾上腺皮质和垂体功能。
Br Med J. 1963 Jul 6;2(5348):24-6. doi: 10.1136/bmj.2.5348.24.
6
Systemic and local corticosteroid therapy in ulcerative colitis.溃疡性结肠炎的全身和局部皮质类固醇治疗。
Br Med J. 1960 Feb 13;1(5171):464-7. doi: 10.1136/bmj.1.5171.464.
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Rectal absorption of 6alpha-(C-14)-methylprednisolone.6α-（碳-14）-甲基泼尼松龙的直肠吸收
Proc Soc Exp Biol Med. 1960 Jan;103:74-7.
8
Intrarectal treatment of 100 cases of ulcerative colitis with prednisolone-21-phosphate enemata.用磷酸泼尼松龙-21-磷酸盐灌肠剂直肠内治疗100例溃疡性结肠炎。
Br Med J. 1961 Jan 21;1(5220):165-8. doi: 10.1136/bmj.1.5220.165.
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A semi-automated fluorimetric procedure for the determination of plasma corticosteroids.
Steroids. 1968 Apr;11(4):497-511. doi: 10.1016/s0039-128x(68)80064-9.
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Radioimmunoassay for prednisolone.
Steroids. 1973 Jun;21(6):833-46. doi: 10.1016/0039-128x(73)90124-4.

给予磷酸泼尼松龙21作为保留灌肠剂后血浆泼尼松龙水平和肾上腺皮质反应性。

Plasma prednisolone levels and adrenocortical responsiveness after administration of prednisolone-21-phosphate as a retention enema.

作者信息

Lee D A, Taylor G M, James V H, Walker G

出版信息

Gut. 1979 May;20(5):349-55. doi: 10.1136/gut.20.5.349.

DOI:10.1136/gut.20.5.349
PMID:223947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1412428/
Abstract

Plasma prednisolone levels have been measured by radioimmunoassay after oral and rectal administration to healthy volunteers and to patients with idiopathic proctocolitis. The amount of prednisolone absorbed from a 20 mg retention enema given to patients with proctocolitis was about 44% of that absorbed from the same dose orally administered. Adrenocortical response to synthetic ACTH in patients receiving prolonged rectal therapy was either normal, or only slightly impaired, and this may be related to the pattern of steroid absorption rather than to the total amount absorbed.

摘要

已通过放射免疫分析法测定了健康志愿者和特发性直肠结肠炎患者口服及直肠给药后的血浆泼尼松龙水平。给予直肠结肠炎患者20mg保留灌肠剂后，泼尼松龙的吸收量约为口服相同剂量后吸收量的44%。接受长期直肠治疗的患者对合成促肾上腺皮质激素的肾上腺皮质反应正常，或仅略有受损，这可能与类固醇的吸收方式有关，而非与吸收总量有关。