Powell-Tuck J, Lennard-Jones J E, May C S, Wilson C G, Paterson J W
Br Med J. 1976 Jan 24;1(6003):193-5. doi: 10.1136/bmj.1.6003.193.
A competitive protein-binding assay was used to measure plasma prednisolone levels after administration of prednisolone-21-phosphate retention enemas to seven patients with colitis. Prednisolone appeared in the plasma of all patients after the enema, and concentrations rose to a peak within three hours. In five of the patients plasma prednisolone levels were also measured after the same dose of prednisolone by mouth. Although in individual patients the plasma levels achieved by enema were often quite different from those achieved by mouth, overall the levels achieved by each mode of administration were of a similar order. These findings suggest that 20 mg prednisolone given by retention enema may well exert a systemic effect.
采用竞争性蛋白结合分析法，对7例结肠炎患者给予磷酸泼尼松龙保留灌肠剂后测定其血浆泼尼松龙水平。灌肠后所有患者血浆中均出现泼尼松龙，且浓度在3小时内升至峰值。其中5例患者还口服相同剂量的泼尼松龙后测定了血浆泼尼松龙水平。虽然个别患者灌肠后达到的血浆水平与口服后达到的水平常有很大差异，但总体而言，每种给药方式达到的水平大致相同。这些发现表明，20mg泼尼松龙保留灌肠很可能会产生全身效应。
