Blumauerová M, Podojil M, Gauze G F, Maksimova T S, Panos J, Vanĕk Z
Folia Microbiol (Praha). 1980;25(3):207-12. doi: 10.1007/BF02877339.
Spontaneous variants of the beromycin-producing strain Streptomyces glomeratus 3980 were divided into five groups (A-E) according to increasing antibiotic activity. The most active variants (group E) differed from the other types and the wild strain by a suppressed ability to produce aerial mycelium and melanoid piogment and by an increased production of propionic acid. Strains with a 12-fold higher antibiotic production capacity (with respect to strain 3980) were obtained by selection of superior segregants from submerged cultures of the E type.
产生博来霉素的菌株球孢链霉菌3980的自发变体根据抗生素活性的增加分为五组（A - E）。活性最高的变体（E组）与其他类型和野生菌株的不同之处在于，其气生菌丝体和类黑色素的产生能力受到抑制，丙酸产量增加。通过从E型深层培养物中筛选优良分离株，获得了抗生素生产能力比菌株3980高12倍的菌株。
