Grumbach M M
Hosp Pract. 1980 Mar;15(3):51-60. doi: 10.1080/21548331.1980.11946569.
The endocrine events that we recognize as adolescent puberty actually begin early in fetal life. The natural history of these developments and the "switches" that turn them on and off are reviewed in terms of both normal and abnormal maturation of sexual function and are related to potential therapeutic approaches. A major focus is on the observation that adrenarche and gonadarche are totally independent events.
我们所认识到的青春期内分泌事件实际上在胎儿期早期就开始了。这些发育的自然史以及开启和关闭它们的“开关”，将根据性功能的正常和异常成熟情况进行回顾，并与潜在的治疗方法相关联。一个主要重点是观察到肾上腺初现和性腺初现是完全独立的事件。
