3型肺炎球菌多糖在大鼠体内的抗原性及保护作用
Antigenicity and protective effects of type 3 pneumococcal polysaccharide in rats.
作者信息
Hodges G R, Worley S E, Degener C E, Clark G M
出版信息
Infect Immun. 1980 Jun;28(3):832-6. doi: 10.1128/iai.28.3.832-836.1980.
The response to type 3 pneumococcal polysaccharide vaccination, the protective effect of type 3 pneumococcal polysaccharide vaccination, and the ability of hemagglutinating antibody to type 3 pneumococcal polysaccharide to cross the blood-brain barrier were studied in rats. Hemagglutinating antibody response to vaccination with type 3 pneumococcal polysaccharide was found to be dependent on the dose and route of inoculation. Intraperitoneal vaccination with type 3 pneumococcal polysaccharide protected the rats from subsequent intraperitoneal challenge with type 3 Streptococcus pneumoniae but had no effect after intracisternal challenge with type 3 S. pneumoniae. In the presence or absence of sterile meningeal inflammation, hemagglutinating antibody could not be found in cerebrospinal fluid of animals vaccinated intraperitoneally with type 3 pneumococcal polysaccharide. These results suggest that type 3 pneumococcal polysaccharide is antigenic in rats and intraperitoneal vaccination with type 3 pneumococcal polysaccharide does not protect against experimental meningitis because antibodies do not cross the blood-brain barrier.
在大鼠中研究了3型肺炎球菌多糖疫苗的反应、3型肺炎球菌多糖疫苗的保护作用以及3型肺炎球菌多糖血凝抗体穿过血脑屏障的能力。发现对3型肺炎球菌多糖疫苗接种的血凝抗体反应取决于接种剂量和途径。用3型肺炎球菌多糖进行腹腔接种可保护大鼠免受随后3型肺炎链球菌腹腔攻击，但在3型肺炎链球菌脑池内攻击后无效。在有无无菌性脑膜炎症的情况下，用3型肺炎球菌多糖腹腔接种的动物脑脊液中均未发现血凝抗体。这些结果表明，3型肺炎球菌多糖在大鼠中具有抗原性，用3型肺炎球菌多糖进行腹腔接种不能预防实验性脑膜炎，因为抗体不能穿过血脑屏障。
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