Coonrod J D, Rylko-Bauer B
Infect Immun. 1976 Jun;13(6):1554-8. doi: 10.1128/iai.13.6.1554-1558.1976.
Hemagglutinating antibody responses of Lewis-Wistar and Sprague-Dawley rats to graded doses of type-specific pneumococcal polysaccharide were measured. Rats given a small dose (0.2 to 50 mug)of type 1 or 8 polysaccharide intraperitoneally developed type-specific hemagglutinating antibody. Rats given larger doses of polysaccharide (greater than or equal to200 mug) did not develop detectable hemagglutinating antibody, and they were unresponsive to a subsequence injection of a small (and normally antigenic) dose of polysaccharide. There was prolonged antigenemia in rats injected with a large dose of polysaccharide. There was prolonged antigenemia in rats injected with a large dose of polysaccharide, and the kinetics of antigen clearance in these animals resembled that reported for mice with polysaccharide immunological paralysis. These results indicate that a phenomenon resembling immunological paralysis with type-specific pneumococcal polysaccharides can be produced in rats.
测定了Lewis-Wistar大鼠和Sprague-Dawley大鼠对不同剂量型特异性肺炎球菌多糖的血凝抗体反应。腹腔注射小剂量(0.2至50微克)1型或8型多糖的大鼠产生了型特异性血凝抗体。给予大剂量多糖(大于或等于200微克)的大鼠未产生可检测到的血凝抗体,并且它们对随后注射的小剂量(且通常具有抗原性)多糖无反应。注射大剂量多糖的大鼠存在抗原血症延长的情况。注射大剂量多糖的大鼠存在抗原血症延长的情况,并且这些动物体内抗原清除的动力学类似于报道的患有多糖免疫麻痹的小鼠的情况。这些结果表明,在大鼠中可以产生类似于型特异性肺炎球菌多糖免疫麻痹的现象。