急性和慢性乙型肝炎病毒感染期间的血清免疫粘连素滴度。
Serum immunoconglutinin titers during acute and chronic hepatitis B virus infection.
作者信息
Makhdoomi G M, Tiku M L, Beutner K R, Ogra P L
出版信息
Infect Immun. 1980 Jun;28(3):842-5. doi: 10.1128/iai.28.3.842-845.1980.
Sera from 99 chronic hepatitis B surface antigen carriers, 12 individuals with acute type B hepatitis, 26 hepatitis B surface antibody-seropositive subjects, and 50 hepatitis B surface antigen, hepatitis B surface antibody-seronegative subjects were evaluated for the presence of serum imunoconglutinis (IKs). The mean serum IK titers of hepatitis B surface antibody-seropositive and hepatitis B virus-seronegative subjects wre 5.3 and 4.9, respectively. The IK titers of subjects with acute and chronic hepatitis B virus infections were 215.4 and 19.1, respectively. These groups also manifested IK titers greater than or equal to > 16 significantly (P < 0.005) more often than controls did. Among chronic hepatitis B surface antigen carriers, high IK titers were associated with low levels of hepatitis B surface antigen. IK titers of individuals chronically infected with hepatitis B virus and having the rheumatoid factor were similar to those of individuals without the rheumatoid factor. Elevated IK titers represent a physiological autoimmune response and may indicate the presence of immune complexes in acute and chronic hepatitis B virus infection.
对99名慢性乙型肝炎表面抗原携带者、12名急性乙型肝炎患者、26名乙型肝炎表面抗体血清学阳性者以及50名乙型肝炎表面抗原、乙型肝炎表面抗体血清学阴性者的血清进行了血清免疫粘连素（IKs）检测。乙型肝炎表面抗体血清学阳性且乙型肝炎病毒血清学阴性者的血清IK平均滴度分别为5.3和4.9。急性和慢性乙型肝炎病毒感染者的IK滴度分别为215.4和19.1。这些组出现IK滴度大于或等于>16的情况显著（P<0.005）多于对照组。在慢性乙型肝炎表面抗原携带者中，高IK滴度与低水平的乙型肝炎表面抗原相关。慢性感染乙型肝炎病毒且患有类风湿因子者的IK滴度与无类风湿因子者相似。IK滴度升高代表一种生理性自身免疫反应，可能表明急性和慢性乙型肝炎病毒感染中存在免疫复合物。
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