你的剂量真的有必要吗？尿路感染中的抗生素剂量。
Is your dosage really necessary? Antibiotic dosage in urinary infection.
作者信息
Greenwood D, O'Grady F
出版信息
Br Med J. 1977 Sep 10;2(6088):665-7. doi: 10.1136/bmj.2.6088.665.
Abstract
Dense cultures of bacteria were exposed to changing concentrations of beta-lactam antibiotics in an in-vitro model of the urinary bladder. The results suggest that uncomplicated urinary infection may respond to lower doses than are usually given without compromising the success of subsequent treatment in those cases in which such minimal treatment fails.
摘要
在膀胱体外模型中，将高密度细菌培养物暴露于浓度不断变化的β-内酰胺类抗生素中。结果表明，对于单纯性泌尿系统感染，在那些最低限度治疗失败的病例中，使用比通常剂量更低的药物可能有效，且不会影响后续治疗的成功率。
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本文引用的文献
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Br J Urol. 1968 Apr;40(2):196-201. doi: 10.1111/j.1464-410x.1968.tb09874.x.
2
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The effect of osmolality on the response of Escherichia coli and Proteus mirabilis to penicillins.渗透压摩尔浓度对大肠杆菌和奇异变形杆菌对青霉素反应的影响。
Br J Exp Pathol. 1972 Oct;53(5):457-64.
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The two sites of penicillin action in Escherichia coli.青霉素在大肠杆菌中的两个作用位点。
J Infect Dis. 1973 Dec;128(6):791-4. doi: 10.1093/infdis/128.6.791.
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Lancet. 1970 May 16;1(7655):1035-6.
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Cefuroxime, a new cephalosporin antibiotic: activity in vitro.头孢呋辛，一种新型头孢菌素抗生素：体外活性
Antimicrob Agents Chemother. 1976 Mar;9(3):511-9. doi: 10.1128/AAC.9.3.511.
7
Activity and interaction of trimethoprim and sulphamethoxazole against Escherichia coli.甲氧苄啶和磺胺甲恶唑对大肠杆菌的活性及相互作用
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