Riser E, Noone P, Howard F M
J Clin Pathol. 1980 Apr;33(4):400-7. doi: 10.1136/jcp.33.4.400.
Of the babies admitted to the Special Care Baby Unit of the Royal Free Hospital over 20 months, 10.2% were infected or colonised by klebsiella. The fluorescent antibody technique was used to identify epidemics caused by three strains: capsular type 8 K. aerogenes, type 68 K. oxytoca, or type 13 K. aerogenes, each of which was predominant at a different time, exhibited a difference in virulence, and showed a predilection for different sites of infection. Intestinal colonisation was frequently followed by the presence of sepsis in other sites by the same capsular type. Antibiotic administration led to a higher incidence of klebsiella infection, while the widespread use of compounds containing hexachlorophane could have contributed to skin colonisation and infection by klebsiella. An environmental survey indicated that 1% Hycolin failed to disinfect the incubators, that the babies were the reservoirs of the organisms, and that transmission was due to inadequate hand-washing of nurses and mothers. The mothers were found to have been uninformed of hygienic techniques. They were observed in various practices which could have contributed to the spread of the organism, including contaminating communal areas and handling babies other than their own. It has been recommended that the mothers of premature infants be instructed in the hygienic measures required in dealing with this susceptible population and that the nursing and medical staff be more strict in their own observance of these procedures.
在皇家自由医院特殊护理婴儿病房收治超过20个月的婴儿中，10.2%受到克雷伯菌感染或定植。荧光抗体技术用于识别由三种菌株引起的疫情：8型产气克雷伯菌、68型产酸克雷伯菌或13型产气克雷伯菌，每种菌株在不同时间占主导地位，毒力不同，且对不同感染部位有偏好。肠道定植后，同一荚膜型菌株常导致其他部位发生败血症。使用抗生素导致克雷伯菌感染发生率更高，而广泛使用含六氯酚的化合物可能导致克雷伯菌皮肤定植和感染。一项环境调查表明，1%的海科林未能对 incubators 进行消毒，婴儿是这些微生物的储存宿主，传播是由于护士和母亲洗手不充分。发现母亲们未被告知卫生技术。观察到她们有各种可能导致病菌传播的行为，包括污染公共区域和接触他人的婴儿。建议指导早产儿母亲掌握应对这一易感人群所需的卫生措施，并建议护理和医务人员更严格地遵守这些程序。 （注：原文中“incubators”未翻译，因为不清楚具体所指，可能是某种医疗设备，需结合更多背景信息确定准确译名）
