Riser E, Noone P
J Clin Pathol. 1981 May;34(5):552-5. doi: 10.1136/jcp.34.5.552.
More than 1750 clinical isolates of klebsiella were collected over a period of six years from two different hospitals and capsular typed by the fluorescent antibody technique. A correlation was made between type and site of isolation. Many types were found to be associated more frequently with one site, which suggested a predilection of some capsular types for certain sites of infection. The site may also be a factor contributing to the virulence of a particular type. A greater antibiotic resistance was often noted in types isolated from their predominant sites; however, antibiograms were not consistent for a type from a given site. The combination of site specificity, resistance, and another 'virulence factor' may all be involved in the determination of a pathogenic strain.
在六年时间里，从两家不同医院收集了1750多株克雷伯菌临床分离株，并采用荧光抗体技术进行荚膜分型。对分离类型与分离部位进行了相关性分析。发现许多类型在一个部位的分离频率更高，这表明某些荚膜类型对特定感染部位有偏好。该部位也可能是导致特定类型毒力的一个因素。从其主要分离部位分离出的菌株类型通常具有更高的抗生素耐药性；然而，来自给定部位的某一类型的抗菌谱并不一致。部位特异性、耐药性和另一种“毒力因子”的组合可能都与致病菌株的确定有关。
