Joiner K A, Gelfand J A, Onderdonk A B, Bartlett J G, Gorbach S L
J Infect Dis. 1980 Jul;142(1):40-9. doi: 10.1093/infdis/142.1.40.
The role of host factors in the formation of subcutaneous abscesses due to Bacteroides fragilis or Staphylococcus aureus was investigated in athymic nude mice, mice deficient in the fifth component of complement (C5D), and mice pretreated with cobra venom factor (CVF). CVF-treated mice, inoculated with B. fragilis, had abscesses 62% larger than those of control mice at day 4 (P < 0.01), but no significant difference was observed when S. aureus was used. Athymic nude mice had significantly smaller abscesses than control animals at both days 4 and 7 after inoculation with either organism. There were no differences in abscess size or in the accumulation of neutrophils at day 4 when C5D mice were compared with control animals for either organism. The results suggested that the activity of the alternative complement pathway may influence abscess size and that chemotactic factors other than the fifth component of complement can supervene in C5D mice to produce encapsulated abscesses. The absence of thymic factors did not prevent containment of abscesses.
在无胸腺裸鼠、缺乏补体第五成分的小鼠（C5D）以及用眼镜蛇毒因子（CVF）预处理的小鼠中，研究了宿主因素在脆弱拟杆菌或金黄色葡萄球菌引起的皮下脓肿形成中的作用。用CVF处理的小鼠接种脆弱拟杆菌后，在第4天脓肿比对照小鼠大62%（P < 0.01），但使用金黄色葡萄球菌时未观察到显著差异。无胸腺裸鼠在接种任何一种细菌后的第4天和第7天，脓肿都明显小于对照动物。当将C5D小鼠与对照动物在接种任何一种细菌后第4天的脓肿大小或中性粒细胞积聚情况进行比较时，未发现差异。结果表明，替代补体途径的活性可能影响脓肿大小，并且除补体第五成分外的趋化因子可在C5D小鼠中起作用，以产生包膜脓肿。胸腺因子的缺乏并不妨碍脓肿的局限化。
