对脆弱拟杆菌荚膜多糖的细胞免疫

Cellular immunity to Bacteroides fragilis capsular polysaccharide.

作者信息

Shapiro M E, Onderdonk A B, Kasper D L, Finberg R W

出版信息

J Exp Med. 1982 Apr 1;155(4):1188-97. doi: 10.1084/jem.155.4.1188.

DOI:10.1084/jem.155.4.1188

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186655/

Abstract

The polysaccharide capsule of Bacteroides fragilis has been shown to be important in the virulence of the organism. The capsular polysaccharide (CP) of B. fragilis has been extensively purified. Using a murine model of intraabdominal abscess formation, we have been able to demonstrate cellular immunity to the capsular polysaccharide of B. fragilis. Immunization of C57BL/10J mice with the CP over 5 wk prevents abscess formation when the mice are challenged with B. fragilis intraperitoneally. This immunity can be transferred to naive mice with spleen cells from immune animals. The immune cells bear Thy-1.2 and Ly-2.2 antigens. The immune response has been shown to be antigen specific, but not H-2 restricted. The possibility that these immune cells are suppressor T cells is discussed. The experimental system presented provides a model for the examination of the cellular interactions responsible for abscess formation and the cellular response to bacterial pathogens.

摘要

脆弱拟杆菌的多糖荚膜已被证明在该生物体的毒力中起重要作用。脆弱拟杆菌的荚膜多糖（CP）已被广泛纯化。使用腹腔脓肿形成的小鼠模型，我们已经能够证明对脆弱拟杆菌荚膜多糖的细胞免疫。用CP对C57BL/10J小鼠进行5周以上的免疫，当小鼠腹腔内受到脆弱拟杆菌攻击时可预防脓肿形成。这种免疫力可以用来自免疫动物的脾细胞转移给未免疫的小鼠。免疫细胞带有Thy-1.2和Ly-2.2抗原。免疫反应已被证明是抗原特异性的，但不受H-2限制。讨论了这些免疫细胞是抑制性T细胞的可能性。所提供的实验系统为研究负责脓肿形成的细胞相互作用以及对细菌病原体的细胞反应提供了一个模型。

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本文引用的文献

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