Ramsden R T, Wilson P, Gibson W P
J Laryngol Otol. 1980 May;94(5):521-31. doi: 10.1017/s0022215100089209.
Immediate electrocochleographic changes have been studied in a series of patients following intravenous infusion of either tobramycin or gentamicin. In patients receiving tobramycin, as soon as peak serum levels of antibiotic were reached, a dramatic decrease occurred in the magnitude of the compound VIII nerve action potential (AP), and of the cochlear microphonic (CM). The shape of the AP also changed. The N1 component of the waveform became very small, and N2 increased in size; this is the dissociated pattern of basal coil cochlear damage. The speed of onset of these electrical changes and their apparent reversibility suggests a temporary metabolic block caused by tobramycin. No such changes were observed following infusion of gentamicin.
在一系列静脉输注妥布霉素或庆大霉素的患者中，研究了即刻的耳蜗电图变化。在接受妥布霉素的患者中，一旦抗生素血清水平达到峰值，复合第八神经动作电位（AP）和耳蜗微音电位（CM）的幅度就会急剧下降。AP的形状也发生了变化。波形的N1成分变得非常小，而N2的大小增加；这是基底回蜗管损伤的分离模式。这些电变化的发生速度及其明显的可逆性表明是由妥布霉素引起的暂时代谢阻滞。输注庆大霉素后未观察到此类变化。
