妥布霉素对人耳蜗的即刻效应及其与血清妥布霉素水平的相关性。
Immediate effects of tobramycin on human cochlea and correlation with serum tobramycin levels.
作者信息
Wilson P, Ramsden R T
出版信息
Br Med J. 1977 Jan 29;1(6056):259-61. doi: 10.1136/bmj.1.6056.259.
Abstract
Electrocochleography was performed on three patients to monitor the intravenous administration of tobramycin. When peak serum tobramycin levels exceeded 8-10 mug/ml an immediate dramatic reduction in cochlear output was observed, which recovered fully as serum levels fell. The patients had no auditory or vestibular symptoms either during or after treatment.
摘要
对三名患者进行了电耳蜗描记术，以监测妥布霉素的静脉给药情况。当血清妥布霉素峰值水平超过8 - 10微克/毫升时，观察到耳蜗输出立即显著降低，随着血清水平下降，耳蜗输出完全恢复。患者在治疗期间及治疗后均无听觉或前庭症状。
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