软骨细胞对胶原蛋白的分解。
The breakdown of collagen by chondrocytes.
作者信息
Jubb R W, Fell H B
出版信息
J Pathol. 1980 Mar;130(3):159-67. doi: 10.1002/path.1711300304.
PMID:7400877
Abstract
The chondrocytes of pure articular cartilage from young pigs display collagenolytic activity when the cartilage is cultivated by an organ culture method in medium containing 5--10 IU retinol/ml. Breakdown of collagen occurs in all regions of the cartilage; in the thicker explants it is greatest and most frequent in those that contain the deepest zone composed of proliferating and hypertrophic chondrocytes; it is also very drastic in thin explants composed mainly of superficial fibro-cartilage.
摘要
采用器官培养法，将幼年猪的纯关节软骨在含有5 - 10国际单位视黄醇/毫升的培养基中培养时，软骨细胞表现出胶原分解活性。软骨的所有区域均发生胶原蛋白降解；在较厚的外植体中，含有由增殖和肥大软骨细胞组成的最深层区域的外植体中胶原蛋白降解最为严重且最频繁；在主要由表层纤维软骨组成的薄外植体中，胶原蛋白降解也非常剧烈。
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