Adhikari M, Coovadia H M, Greig H B, Christensen S
Nephron. 1978;22(4-6):301-5. doi: 10.1159/000181466.
Plasma factor VIII procoagulant activity has been shown to be significantly elevated in 32 children with the nephrotic syndrome. This increase is more marked in those with obvious glomerular lesions on histology than in patients with minimal change nephropathy. Fluctuations in factor VIII levels corresponded to changes in the clinical condition of the nephrotic syndrome. In 28 children with post-streptococcal glomerulonephritis, 4 patients with the highest factor VIII levels recovered between 7 and 60 days of onset of disease whereas the remainder did so in less than 7 days. Factor VIII levels may reflect the extent of immunopathological injury to glomerular capillaries and be useful in management of children with glomerular disease.
血浆凝血因子VIII促凝血活性在32例肾病综合征患儿中显著升高。组织学上有明显肾小球病变的患儿，其升高更为明显，高于微小病变肾病患者。凝血因子VIII水平的波动与肾病综合征临床状况的变化相对应。在28例链球菌感染后肾小球肾炎患儿中，4例凝血因子VIII水平最高的患者在疾病发作后7至60天内康复，其余患者在不到7天内康复。凝血因子VIII水平可能反映肾小球毛细血管免疫病理损伤的程度，对肾小球疾病患儿的治疗有帮助。
