Seelig H P, Seelig R, Schärer K
Z Kinderheilkd. 1975 Aug 11;120(2):111-20.
A 10-month-old infant developed a steroid resistant nephrotic syndrome. The renal biopsy revealed diffuse mesangial sclerosis of the glomerula. The child died from interstitial pneumonia 3 months after onset of the renal symptoms. Post mortem, the glomerular changes were diffuse but prominent in certain segments of the glomeruli. The immunohistological examination showed granular deposits of IgM and C3 in the mesangium and in the subendothelial region of the basement membrane. These findings are compatible with the hypothesis that diffuseal sclerosis is caused by glomerular deposition of immune complexes.
一名10个月大的婴儿患上了类固醇抵抗型肾病综合征。肾活检显示肾小球弥漫性系膜硬化。该患儿在出现肾脏症状3个月后死于间质性肺炎。尸检时，肾小球变化是弥漫性的，但在肾小球的某些节段较为突出。免疫组织学检查显示系膜和基底膜内皮下区域有IgM和C3颗粒状沉积。这些发现与弥漫性硬化是由免疫复合物在肾小球沉积所致这一假说相符。
