Prout G R, Heaney J A, Griffin P P, Daly J J, Shipley W U
J Urol. 1980 Aug;124(2):226-31. doi: 10.1016/s0022-5347(17)55382-3.
Between 1969 and 1976, 92 patients with proved prostatic carcinoma in stages T0 and T4 underwent pelvic lymphadenectomy. Median followup has been 43 months. All patients had normal serum acid phosphatase levels and no clinical evidence of metastases as determined by physical examination, bone scans and metastatic bone surveys. Pelvic lymph node metastases were noted in 32 cases. Radical prostatectomy was done in 34 cases and 45 patients received radiotherapy, 11 of whom had 125iodine seeds implanted. Progression of the neoplastic process, almost exclusively in the form of bony metastases, occurred in 18 of the 32 patients who had positive pelvic nodes and in 6 of the 60 patients with negative nodes (p less than 0.001). Patients with poorly differentiated carcinoma were more likely to have progression of the disease than those with moderately differentiated carcinoma (p less than 0.01) and no patient with a well differentiated carcinoma had disease progression.
1969年至1976年间，92例经证实为T0期和T4期前列腺癌的患者接受了盆腔淋巴结清扫术。中位随访时间为43个月。所有患者血清酸性磷酸酶水平均正常，且经体格检查、骨扫描和转移性骨检查未发现临床转移证据。32例发现盆腔淋巴结转移。34例行根治性前列腺切除术，45例患者接受放疗，其中11例植入了125碘籽源。在32例盆腔淋巴结阳性的患者中，18例出现肿瘤进展，几乎均为骨转移形式；在60例盆腔淋巴结阴性的患者中，6例出现肿瘤进展（p<0.001）。低分化癌患者比中分化癌患者更易出现疾病进展（p<0.01），而高分化癌患者无疾病进展。
