Blaivas J G, Labib K B, Michalik S J, Zayed A A
J Urol. 1980 Aug;124(2):259-62. doi: 10.1016/s0022-5347(17)55398-7.
We studied 42 patients with urinary incontinence who demonstrated uninhibited detrusor contractions during cystometry. Each patient underwent urodynamic evaluation before and after the parenteral administration of propantheline bromide. Of these 42 patients 33 (79 per cent) had a positive response to propantheline: total abolition of uninhibited bladder contractions or 200 per cent increase in bladder capacity. Of these 33 patients 26 were treated with the oral drug and all but 1 had complete clinical response. Urinary retention occurred in half of the patients. These patients were managed with intermittent self-catheterization in addition to oral propantheline. None of the patients who failed to respond to the parenteral medication had a favorable response to the orally administered drug.
我们研究了42例尿失禁患者，这些患者在膀胱测压时表现出逼尿肌无抑制性收缩。每位患者在胃肠外给予溴丙胺太林前后均接受了尿动力学评估。在这42例患者中，33例（79%）对溴丙胺太林有阳性反应：无抑制性膀胱收缩完全消失或膀胱容量增加200%。在这33例患者中，26例接受了口服药物治疗，除1例患者外，其余患者均有完全的临床反应。一半的患者出现了尿潴留。除口服溴丙胺太林外，这些患者还通过间歇性自我导尿进行处理。对胃肠外用药无反应的患者中，没有一例对口服药物有良好反应。
