Schumpelick V, Schassan H H
Langenbecks Arch Chir. 1980;350(4):271-9. doi: 10.1007/BF01237638.
The intergastric bacterial flora was studied in 125 patients after different types of ulcer operations and correlated with pH value and histological state of gastric mucosa. Following vagotomy most of the gastric juices were sterile whereas more than 60% of the resected stomach were contaminated with fecal and oropharyngeal flora. After jejunal transposition the proportion of fecal flora was reduced to one-third. There was a good correlation between bacterial overgrowth and pH value. Only 10-20% of the stomachs with pH values lower than 4.5 and more than 80% of the stomachs with pH values above 6 were bacterially contaminated. Intragastric flora was found in 90% of the stomachs with atrophic gastritis. The synergistic role of intragastric bacterial flora in carcinogenesis by deconjugation of the bile acids and production of nitrosamine is emphasized.
对125例接受不同类型溃疡手术的患者的胃内细菌菌群进行了研究,并将其与胃黏膜的pH值和组织学状态相关联。迷走神经切断术后,大多数胃液无菌,而超过60%的切除胃被粪便和口咽菌群污染。空肠移位术后,粪便菌群比例降至三分之一。细菌过度生长与pH值之间存在良好的相关性。pH值低于4.5的胃中只有10%-20%被细菌污染,而pH值高于6的胃中有超过80%被细菌污染。90%的萎缩性胃炎患者胃内存在菌群。强调了胃内细菌菌群通过胆汁酸去结合和亚硝胺生成在致癌过程中的协同作用。