胃手术后细菌定植、亚硝酸盐及亚硝胺生成的实验研究
An experimental study on bacterial colonization, nitrite and nitrosamine production in the operated stomach.
作者信息
Böckler R, Meyer H, Schlag P
出版信息
J Cancer Res Clin Oncol. 1983;105(1):62-6. doi: 10.1007/BF00391833.
Abstract
Intragastric bacterial growth and nitrite and nitrosamine formation were investigated in animal experiments after different surgical procedures of ulcer management with regard to carcinogenesis in the operated stomach. The operative procedures resulted in an alteration in the gastric flora with an increase and predominance of nitrate-reducing bacteria. There was an increase in the intragastric nitrite and nitrosamine concentration corresponding to the increase in nitrate-reducing bacteria. All three parameters showed the greatest increase after gastric resection, whereas there were no significant differences after vagotomy with pyloroplasty, compared with a control group. These findings in animal experiments are of etiopathological relevance to the known danger of cancer in the resected human stomach and should be taken into consideration when choosing a procedure for surgical ulcer therapy.
摘要
在动物实验中，针对溃疡治疗的不同外科手术方式对手术胃部癌变的影响，研究了胃内细菌生长以及亚硝酸盐和亚硝胺的形成。手术操作导致胃内菌群发生改变，硝酸盐还原菌增加并占主导地位。胃内亚硝酸盐和亚硝胺浓度随着硝酸盐还原菌的增加而升高。这三个参数在胃切除术后增加最为显著，而与对照组相比，迷走神经切断术加幽门成形术后无显著差异。动物实验中的这些发现与人类胃切除术后已知的癌症风险具有病因学相关性，在选择手术治疗溃疡的方式时应予以考虑。
相似文献
1
An experimental study on bacterial colonization, nitrite and nitrosamine production in the operated stomach.胃手术后细菌定植、亚硝酸盐及亚硝胺生成的实验研究
J Cancer Res Clin Oncol. 1983;105(1):62-6. doi: 10.1007/BF00391833.
2
Medical versus surgical treatment for refractory or recurrent peptic ulcer.难治性或复发性消化性溃疡的内科治疗与外科治疗
Cochrane Database Syst Rev. 2016 Mar 29;3(3):CD011523. doi: 10.1002/14651858.CD011523.pub2.
3
Gastric-juice nitrite. A risk factor for cancer in the hypochlorhydric stomach?胃液亚硝酸盐。胃酸过少的胃中癌症的一个风险因素？
Lancet. 1976 Nov 13;2(7994):1037-9. doi: 10.1016/s0140-6736(76)90962-4.
4
A systematic review and dose‒response meta-analysis of the association between nitrate & nitrite intake and gastroesophageal cancer risk.硝酸盐和亚硝酸盐摄入与胃癌和食管癌风险关联的系统评价和剂量-反应荟萃分析。
Nitric Oxide. 2024 Dec 1;153:61-71. doi: 10.1016/j.niox.2024.10.007. Epub 2024 Oct 12.
5
What is the value of routinely testing full blood count, electrolytes and urea, and pulmonary function tests before elective surgery in patients with no apparent clinical indication and in subgroups of patients with common comorbidities: a systematic review of the clinical and cost-effective literature.在没有明显临床指征的患者和常见合并症患者亚组中，在择期手术前常规检测全血细胞计数、电解质和尿素以及肺功能测试的价值：对临床和成本效益文献的系统评价。
Health Technol Assess. 2012 Dec;16(50):i-xvi, 1-159. doi: 10.3310/hta16500.
6
[Volume and health outcomes: evidence from systematic reviews and from evaluation of Italian hospital data].[容量与健康结果：来自系统评价和意大利医院数据评估的证据]
Epidemiol Prev. 2013 Mar-Jun;37(2-3 Suppl 2):1-100.
7
Nitrate and nitrite contamination in drinking water and cancer risk: A systematic review with meta-analysis.饮用水中的硝酸盐和亚硝酸盐污染与癌症风险：一项系统评价与荟萃分析
Environ Res. 2022 Jul;210:112988. doi: 10.1016/j.envres.2022.112988. Epub 2022 Feb 22.
8
Population-based interventions for reducing sexually transmitted infections, including HIV infection.基于人群的减少性传播感染（包括艾滋病毒感染）的干预措施。
Cochrane Database Syst Rev. 2004(2):CD001220. doi: 10.1002/14651858.CD001220.pub2.
9
Antibiotics and antiseptics for venous leg ulcers.用于下肢静脉溃疡的抗生素和防腐剂
Cochrane Database Syst Rev. 2013 Dec 23(12):CD003557. doi: 10.1002/14651858.CD003557.pub4.
10
Intracavity lavage and wound irrigation for prevention of surgical site infection.腔内灌洗和伤口冲洗预防手术部位感染
Cochrane Database Syst Rev. 2017 Oct 30;10(10):CD012234. doi: 10.1002/14651858.CD012234.pub2.
引用本文的文献
1
The gut-liver axis in sepsis: interaction mechanisms and therapeutic potential.脓毒症的肠-肝轴：相互作用机制和治疗潜力。
Crit Care. 2022 Jul 13;26(1):213. doi: 10.1186/s13054-022-04090-1.
2
Dietary protective and risk factors for esophageal and stomach cancers in a low-epidemic area for stomach cancer in Jiangsu Province, China: comparison with those in a high-epidemic area.中国江苏省胃癌低发地区食管癌和胃癌的膳食保护因素及风险因素：与高发地区的比较
Jpn J Cancer Res. 2001 Nov;92(11):1157-65. doi: 10.1111/j.1349-7006.2001.tb02135.x.
3
Protective effect of allium vegetables against both esophageal and stomach cancer: a simultaneous case-referent study of a high-epidemic area in Jiangsu Province, China.葱属蔬菜对食管癌和胃癌的保护作用：中国江苏省某高发病区的一项同步病例对照研究。
Jpn J Cancer Res. 1999 Jun;90(6):614-21. doi: 10.1111/j.1349-7006.1999.tb00791.x.
4
Bacterial catalysis of nitrosation: involvement of the nar operon of Escherichia coli.细菌催化亚硝化作用：大肠杆菌nar操纵子的参与
J Bacteriol. 1988 Jan;170(1):359-64. doi: 10.1128/jb.170.1.359-364.1988.
5
Mechanism for nitrosation of 2,3-diaminonaphthalene by Escherichia coli: enzymatic production of NO followed by O2-dependent chemical nitrosation.大肠杆菌对2,3-二氨基萘进行亚硝化的机制：酶促产生一氧化氮，随后进行依赖氧气的化学亚硝化。
Appl Environ Microbiol. 1988 Jul;54(7):1791-4. doi: 10.1128/aem.54.7.1791-1794.1988.
6
Proline is not useful as a chemical probe to measure nitrosation in the gastrointestinal tract of patients with gastric disorders characterised by anacidic conditions.脯氨酸作为一种化学探针，对于测量患有以胃酸缺乏为特征的胃部疾病患者胃肠道中的亚硝化作用并无用处。
Gut. 1989 Aug;30(8):1068-75. doi: 10.1136/gut.30.8.1068.
本文引用的文献
1
[Bacteriology of the stomach after operation (author's transl)].手术后胃的细菌学（作者译）
Langenbecks Arch Chir. 1980;350(4):271-9. doi: 10.1007/BF01237638.
2
Frequency of cancerous and precancerous epithelial lesions in the stomach in different models for enterogastric reflux.不同肠胃反流模型中胃内癌性和癌前上皮病变的发生率
Scand J Gastroenterol Suppl. 1981;67:165-8.
3
Carcinogenicity of N-nitroso compounds. Species and route differences in regard to organotropism.N-亚硝基化合物的致癌性。关于器官嗜性的物种和途径差异。
Oncology. 1980;37(4):237-42. doi: 10.1159/000225444.
4
Gastric juice N-nitrosamines in health and gastroduodenal disease.健康及胃十二指肠疾病中的胃液N-亚硝胺
Lancet. 1981 Sep 12;2(8246):550-2. doi: 10.1016/s0140-6736(81)90939-9.
5
Are nitrite and N-nitroso compounds in gastric juice risk factors for carcinoma in the operated stomach?胃液中的亚硝酸盐和N-亚硝基化合物是胃切除术后发生胃癌的危险因素吗？
Lancet. 1980 Apr 5;1(8171):727-9. doi: 10.1016/s0140-6736(80)91229-5.
6
Formation of N-nitrosamines from secondary amines and nitrite in human and animal gastric juice.人和动物胃液中仲胺与亚硝酸盐反应生成N-亚硝胺。
Food Cosmet Toxicol. 1969 Jul;7(4):301-7. doi: 10.1016/s0015-6264(69)80366-4.
7
[A method for the demonstration of nitrosamines].
Hoppe Seylers Z Physiol Chem. 1967 Jul;348(7):852-4.
8
Bacteria and the N-nitrosation of secondary amines.细菌与仲胺的N-亚硝化作用
Br J Cancer. 1971 Sep;25(3):520-6. doi: 10.1038/bjc.1971.66.
9
Studies on the intestinal flora. I. The bacterial flora of the gastrointestinal tract in healthy and achlorhydric persons.肠道菌群研究。I. 健康人和胃酸缺乏者胃肠道的细菌菌群。
Gastroenterology. 1969 Jan;56(1):71-9.
10
[Methods of bacteriological feces examination].
Zentralbl Bakteriol Orig. 1966 Jul;200(3):405-16.
Zotero 插件