Schlag P, Böckler R, Ulrich H, Peter M, Merkle P, Herfarth C
Langenbecks Arch Chir. 1980;350(4):281-6. doi: 10.1007/BF01237639.
The concentration of nitrite and N-nitroso compounds was examined in the fasting gastric juice of 44 patients with regard to the known cancer risk to the operated stomach. All patients had surgery for therapy of an ulcer disease. The operation had taken place an average of 2.5 years previously. Enlisted as a control group were 26 age-matched individuals with healthy stomachs. The concentration of nitrite and N-nitroso compounds in the gastric juice of the vagotomized patiens (PGV) did not differ from that of the controls. On the other hand, a significant increase of the nitrite concentration was found in the gastric juice of those patients resected according to the Billroth I or II procedures. The fraction of N-nitroso compounds, however, was significantly elevated in relation to the other gastric juice samples only in the Billroth II resected stomach. The importance of the increase of nitrite and N-nitroso compounds to the cancer risk inherent in the gastric stump is the subject of discussion.
针对已知的残胃癌症风险，对44例患者空腹胃液中的亚硝酸盐和N-亚硝基化合物浓度进行了检测。所有患者均因溃疡病接受手术治疗。手术平均在2.5年前进行。选取26名年龄匹配的健康胃部个体作为对照组。迷走神经切断术患者（PGV）胃液中的亚硝酸盐和N-亚硝基化合物浓度与对照组无差异。另一方面，在按照毕罗Ⅰ式或Ⅱ式手术切除的患者胃液中，发现亚硝酸盐浓度显著升高。然而，仅在毕罗Ⅱ式切除的胃中，N-亚硝基化合物的比例相对于其他胃液样本显著升高。亚硝酸盐和N-亚硝基化合物浓度升高对残胃癌风险的影响是讨论的主题。
