15-氢过氧二十碳四烯酸抑制人血小板聚集。
15-Hydroperoxyeicosatetraenoic acid inhibits human platelet aggregation.
作者信息
Vericel E, Lagarde M
出版信息
Lipids. 1980 Jun;15(6):472-4. doi: 10.1007/BF02534075.
PMID:7401944
Abstract
Using human platelets isolated from their plasma, we showed that 15-hydroperoxyu-eicosatetraenoic acid (15-HPETE) inhibits platelet aggregation induced either by arachidonic acid or prostaglandin H2 analog. 15-HPETE does not modify platelet prostaglandin and thromboxane formation from exogenous arachidonic acid but does decrease platelet lipoxygenase activity.
摘要
利用从血浆中分离出的人血小板，我们发现15-氢过氧二十碳四烯酸（15-HPETE）可抑制由花生四烯酸或前列腺素H2类似物诱导的血小板聚集。15-HPETE不会改变外源性花生四烯酸生成血小板前列腺素和血栓素的过程，但会降低血小板脂氧合酶的活性。
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