软骨骨髓提取物对骨关节炎软骨中胶原蛋白代谢的影响。
Effect of cartilage bone marrow extract on the metabolism of collagen in osteoarthrotic cartilage.
作者信息
Adam M, Musilova J, Krabcova M, Brettschneider I, Pesakova V, Deyl Z
出版信息
Pharmacology. 1980;21(1):53-8. doi: 10.1159/000137415.
The effect of cartilage bone marrow extract (CBME) on the metabolism of collagen and proteoglycan in crude embryo and human cartilage was investigated. While in chick embryos' articular cartilages the increased levels of radioactivity in collagen and proteoglycan were observed, in normal human cartilage only slight changes were detected. In osteoarthrotic cartilages, however, a marked increase in radioactivity was found in collagen and in the proteoglycan fraction containing the glycoprotein link. A blockade of collagenolysis by CBME treatment is suggested.
研究了软骨骨髓提取物（CBME）对粗制胚胎和人软骨中胶原蛋白和蛋白聚糖代谢的影响。在鸡胚关节软骨中，观察到胶原蛋白和蛋白聚糖中放射性水平升高，而在正常人软骨中仅检测到轻微变化。然而，在骨关节炎软骨中，胶原蛋白和含有糖蛋白连接的蛋白聚糖部分的放射性显著增加。提示CBME处理可阻断胶原溶解。
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