von Knorring Lars, Almay Bela G L, Johansson Folke, Terenius Lars
Departments of Psychiatry and Neurology, University Hospital, 901 85 Umeå, Sweden Department of Pharmacology, University of Uppsala, Uppsala, Sweden.
Pain. 1978 Dec;5(4):359-365. doi: 10.1016/0304-3959(78)90004-0.
In 45 consecutive patients with chronic pain syndromes endorphins, fraction I of the cerebrospinal fluid and pain measures by means of electric stimulation via saline electrodes were investigated. In patients with high levels of fraction I (above median) pain threshold, PT and tolerance level, TL, in condition C (continuous stimulation increase) were found to be significantly higher than in patients with low levels of fraction I (below median). The results indicate that the endorphins are one of the physiological factors that contribute to the pain threshold and the tolerance level.
对45例连续的慢性疼痛综合征患者的内啡肽、脑脊液I组分以及通过盐水电极进行电刺激测量疼痛的情况进行了研究。I组分水平高（高于中位数）的患者，在条件C（连续刺激增加）下的疼痛阈值、PT（痛阈）和耐受水平TL，显著高于I组分水平低（低于中位数）的患者。结果表明，内啡肽是影响疼痛阈值和耐受水平的生理因素之一。
