镇痛性电刺激后人脑室脑脊液中β-内啡肽样免疫反应性的出现。
Appearance of beta-endorphin-like immunoreactivity in human ventricular cerebrospinal fluid upon analgesic electrical stimulation.
作者信息
Akil H, Richardson D E, Barchas J D, Li C H
出版信息
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5170-2. doi: 10.1073/pnas.75.10.5170.
Abstract
beta-Endorphin-like immunoreactivity in human ventricular cerebrospinal fluid was measured with a specific radioimmunoassay. The subjects were undergoing a surgical procedure for relief of chronic intractable pain. This procedure involved the focal stimulation of a medial thalamic site adjacent to the wall of the third ventricle. Samples were collected before and during the analgesic stimulation. No beta-endorphin-like immunoreactivity could be detected prior to stimulation, suggesting that baseline levels are below 25 fmol/ml of cerebrospinal fluid. Electrical stimulation led to substantial increases (13- to 20-fold) in immunoreactive material in every subject. These results suggest that beta-endorphin-like material can be released into the ventricular system and may contribute to the pain blockade that results from periventricular stimulation.
摘要
采用特异性放射免疫分析法测定了人脑室脑脊液中β-内啡肽样免疫反应性。受试者正在接受手术以缓解慢性顽固性疼痛。该手术包括对邻近第三脑室壁的丘脑内侧部位进行局部刺激。在镇痛刺激前和刺激期间采集样本。刺激前未检测到β-内啡肽样免疫反应性，这表明脑脊液的基线水平低于25 fmol/ml。电刺激导致每个受试者的免疫反应性物质大幅增加（13至20倍）。这些结果表明，β-内啡肽样物质可释放到脑室系统中，并可能有助于室周刺激所导致的疼痛阻滞。
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本文引用的文献
1
Analgesia from electrical stimulation in the brainstem of the rat.
Science. 1971 Dec 24;174(4016):1351-4. doi: 10.1126/science.174.4016.1351.
2
Behavioral and electrophysiological evidence of pain inhibition from midbrain stimulation in the cat.
Exp Brain Res. 1974 Apr 30;20(1):32-44. doi: 10.1007/BF00239016.
3
[Comparison in the rat between analgesia induced by stimulation of periacqueducal gray matter and morphine analgesia].
C R Acad Hebd Seances Acad Sci D. 1972 Jun 26;274(26):3603-5.
4
Opioid agonist activity of beta-lipotropin fragments: a possible biological source of morphine-like substances in the pituitary.
FEBS Lett. 1976 Apr 15;64(1):181-4. doi: 10.1016/0014-5793(76)80278-5.
5
Antagonism of stimulation-produced analgesia by naloxone, a narcotic antagonist.
Science. 1976 Mar 5;191(4230):961-2. doi: 10.1126/science.1251210.
6
Stimulation-produced analgesia: development of tolerance and cross-tolerance to morphine.
Science. 1975 May 30;188(4191):941-3. doi: 10.1126/science.1094537.
7
Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1821-3. doi: 10.1073/pnas.73.6.1821.
8
Isolation, characterization and opiate activity of beta-endorphin from human pituitary glands.
Biochem Biophys Res Commun. 1976 Oct 18;72(4):1542-7. doi: 10.1016/s0006-291x(76)80189-1.
9
Physical dependence of opiate-like peptides.
Science. 1976 Sep 24;193(4259):1262-3. doi: 10.1126/science.986687.
10
Isolation of peptides with opiate activity from sheep and human pituitaries: relationship to beta-lipotropin.
Biochem Biophys Res Commun. 1976 Sep 20;72(2):472-8. doi: 10.1016/s0006-291x(76)80066-6.
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