脑脊液中内啡肽浓度的年周期变化。

Circannual variation in concentrations of endorphins in cerebrospinal fluid.

作者信息

von Knorring L, Almay B G L, Johansson F, Terenius L, Wahlström A

机构信息

Department of Psychiatry, University of Umeå, S-901 85 Umeå, Sweden Department of Neurology, University of Umeå, S-901 85 Umeå, Sweden Department of Pharmacology, Uppsala University, UppsalaSweden.

出版信息

Pain. 1982 Mar;12(3):265-272. doi: 10.1016/0304-3959(82)90158-0.

DOI:10.1016/0304-3959(82)90158-0

PMID:7078987

Abstract

In a series of 90 patients with chronic pain syndromes of psychogenic and organic etiology, the concentrations of fraction I endorphins in cerebrospinal fluid were investigated. A significant circannual variation in the concentrations of endorphins was found, with the highest concentrations in January-February and the lowest concentrations in July-August. There was no corresponding seasonal variation with regard to age, sex, bodylength, possible etiology of the pain syndrome self-rated pain levels, or experimental pain measures. Circannual difference in the intensity of symptoms in chronic pain syndromes and in affective disorders have been described in the literature. The present results suggest an association between these observations, giving further support for functional importance of endorphins in chronic pain.

摘要

在一系列90例患有心因性和器质性病因慢性疼痛综合征的患者中，对脑脊液中I组分内啡肽的浓度进行了研究。发现内啡肽浓度存在显著的年周期变化，1月至2月浓度最高，7月至8月浓度最低。在年龄、性别、体长、疼痛综合征可能的病因、自评疼痛水平或实验性疼痛测量方面，没有相应的季节变化。文献中已描述了慢性疼痛综合征和情感障碍中症状强度的年周期差异。目前的结果表明这些观察结果之间存在关联，进一步支持了内啡肽在慢性疼痛中的功能重要性。