Byars N E, Ferraresi R W
Agents Actions. 1980 Jun;10(3):252-7. doi: 10.1007/BF02025944.
Adverse reactions to food may, in some cases, be due to IgE-mediated immune reactions to the ingested antigens. A mast cell protector has been shown to protect patients against challenge with food to which they are sensitive. An IgE-mediated intestinal anaphylaxis reaction in the rat has been developed as a model of some aspects of human food allergy. Using this model, a number of xanthones and other anti-inflammatory agents were tested for activity in inhibiting intestinal anaphylaxis. The compounds were also tested for inhibitory activity against the IgE-mediated rat passive cutaneous anaphylaxis reactions. The xanthones protected against both reactions, as did isoproterenol and cyproheptadine, while aspirin, indomethacin, and dexamethasone inhibited the intestinal but not the cutaneous reaction. This suggests that while IgE-triggered mediator release from mast cells is important in both reactions, other mechanisms may also be operative in the intestinal reaction. Furthermore, the use of xanthones and other anti-inflammatory compounds may be a useful mode of therapy in human food allergy.
在某些情况下，食物不良反应可能是由于对摄入抗原的IgE介导的免疫反应所致。已证明一种肥大细胞保护剂可保护患者免受其敏感食物激发试验的影响。已建立大鼠IgE介导的肠道过敏反应模型，用于模拟人类食物过敏的某些方面。利用该模型，测试了多种氧杂蒽酮和其他抗炎剂抑制肠道过敏反应的活性。还测试了这些化合物对IgE介导的大鼠被动皮肤过敏反应的抑制活性。氧杂蒽酮以及异丙肾上腺素和赛庚啶可预防这两种反应，而阿司匹林、吲哚美辛和地塞米松可抑制肠道反应，但不能抑制皮肤反应。这表明，虽然肥大细胞释放由IgE触发的介质在两种反应中都很重要，但其他机制也可能在肠道反应中起作用。此外，使用氧杂蒽酮和其他抗炎化合物可能是治疗人类食物过敏的一种有效方法。
