Heal A V, Gluck J
Am J Obstet Gynecol. 1980 Aug 15;137(8):975-7. doi: 10.1016/s0002-9378(16)32842-3.
Serum levels of human placental lactogen (hPL) were measured by radioimmunoassay, and a method was developed for the detection of an hPL-binding substance by radioassay. Three groups of women were investigated: (1) normal adult women who had never been pregnant; (2) women with normal pregnancies; (3) high-risk pregnant women (those demonstrating low levels of hPL). All women who had never been pregnant and most women who had normal hPL levels were found to be negative for the hPL-binding substance, whereas 80% of the women with hPL levels less than 4.0 nanograms per mililiter in the third trimester were positive for the hPL-binding substance. The presence of an hPL-binding substance might have a significant effect on pregnancy, since it could bind and reduce the functional availablity of hPL or disrupt normal production of it, thus causing fetal loss or premature delivery.
采用放射免疫分析法测定血清中人胎盘催乳素（hPL）水平，并开发了一种通过放射测定法检测hPL结合物质的方法。研究了三组女性：（1）从未怀孕的正常成年女性；（2）正常妊娠女性；（3）高危孕妇（hPL水平低的孕妇）。发现所有从未怀孕的女性以及大多数hPL水平正常的女性hPL结合物质检测呈阴性，而孕晚期hPL水平低于每毫升4.0纳克的女性中，80%的hPL结合物质检测呈阳性。hPL结合物质的存在可能对妊娠有重大影响，因为它可能结合并降低hPL的功能可用性或干扰其正常产生，从而导致胎儿丢失或早产。
