Miyamoto T, Akiyama K, Ohta K, Hayakawa T, Horiuchi Y
Ann Allergy. 1980 Aug;45(2):108-14.
Effect of oral administration of mite antigen was studied in homocytotropic antibody production in mice. Anti-mite IgE and IgG, antibodies were undetectable if the large amount of mite antigen was given prior to primary immunization. It was noted that the larger the dosage given the more clearly the suppression of homocytotropic antibody production was obtained and the shorter the interval between feeding and primary immunization the more marked tolerance was induced. No significant effect was observed by oral administration of antigen in on-going homocytotropic antibodies.
研究了口服螨抗原对小鼠亲同种细胞抗体产生的影响。如果在初次免疫前给予大量螨抗原，则检测不到抗螨IgE和IgG抗体。值得注意的是，给予的剂量越大，亲同种细胞抗体产生的抑制作用越明显，喂食与初次免疫之间的间隔越短，诱导的耐受性越显著。口服抗原对正在产生的亲同种细胞抗体没有显著影响。
