Opree W
Acta Allergol. 1976 Aug;31(4):321-36.
Formation of specific IgE antibodies as elicited in Sprague-Dawley rats against Ascaris antigen could be suppressed by intravenous administration both of antigen and of specific antiserum. The suppressive agent in the antiserum was shown to be antibodies of the IgG class, whereas a suppressive effect of cytophilic activity and of IgE antibodies could be outruled. Suppression of IgE response lasted the longer the more antibodies were transferred. An antibody-induced suppression was achieved when antibodies were transferred during an early period (day -3 to day +8), whereas an antigen-induced suppression took place when the antigen was intravenously administered following the antibody-sensitive period (day +8 until day +14). This is consistent with the fact that an antigen-induced suppression of IgE formation requires the presence of a certain amount of antibodies. A strictly peripheric suppression could be outruled, since with elapse of time a decreasing dose of antigen was required to induce a suppression. The results are discussed on the basis of an antigen-antibody complex-induced suppression in the IgE system and its possible central site of action.
在斯普拉格-道利大鼠中，针对蛔虫抗原产生的特异性IgE抗体的形成，可通过静脉注射抗原和特异性抗血清来抑制。抗血清中的抑制因子被证明是IgG类抗体，而亲细胞活性和IgE抗体的抑制作用可以排除。IgE反应的抑制持续时间越长，转移的抗体就越多。当在早期（-3天至+8天）转移抗体时，可实现抗体诱导的抑制，而当在抗体敏感期（+8天至+14天）后静脉注射抗原时，则发生抗原诱导的抑制。这与抗原诱导的IgE形成抑制需要一定量抗体存在这一事实是一致的。由于随着时间的推移，诱导抑制所需的抗原剂量逐渐减少，因此可以排除严格的外周抑制。基于IgE系统中抗原-抗体复合物诱导的抑制及其可能的作用中心位点对结果进行了讨论。
