De Macedo M S, Catty D
Immunology. 1977 Nov;33(5):611-9.
The effect of X irradiation on homocytotropic and agglutinating antibody production was studied in mice exposed to 400 rad either before or after immunization with dinitrophenylated Ascaris plus aluminium hydroxide as adjuvant. The adjuvant effect of irradiation was also determined in animals receiving antigen alone. Irradiation 1 day before immunization with adjuvant enhanced IgE and slightly enhanced IgM-antibody formation, although the onset was delayed, but partially suppressed IgG-antibody formation. When the same treatment followed antigen priming, there was a similar enhancement of IgE production which varied with the time between the two procedures. IgG AND IgM production, however, were fairly resistant under the same conditions. Irradiation preceding immunization with soluble antigen had no significant adjuvant effect on IgE-, IgG- or IgM-antibody production. On the contrary, it suppressed production of the latter two classes. The results may indicate that production of IgE and IgG and IgM antibodies in the mouse is regulated by separate mechanisms.
在用二硝基苯基化蛔虫加氢氧化铝作为佐剂免疫小鼠之前或之后，对接受400拉德X射线照射的小鼠进行了研究，以探讨X射线照射对亲同种细胞抗体和凝集抗体产生的影响。还在仅接受抗原的动物中测定了照射的佐剂效应。在用佐剂免疫前1天进行照射可增强IgE并略微增强IgM抗体的形成，尽管其起始时间延迟，但部分抑制了IgG抗体的形成。当在抗原致敏后进行相同处理时，IgE产生有类似的增强，其增强程度随两次处理之间的时间而变化。然而，在相同条件下，IgG和IgM的产生相当稳定。用可溶性抗原免疫前进行照射对IgE、IgG或IgM抗体的产生没有显著的佐剂效应。相反，它抑制了后两类抗体的产生。结果可能表明，小鼠中IgE、IgG和IgM抗体的产生受不同机制的调节。
