Huang J, Gentry R F, Zarkower A
Am J Vet Res. 1980 Apr;41(4):469-73.
In a series of experiments, SMEDI A--porcine enterovirus serotype 8--was given by intrauterine route to pregnant gilts at intervals between gestation days 0 and 30, and SMEDI C-porcine enterovirus serotype 1--was given to pregnant gilts at intervals between gestation days 30 and 41 to 43. Antibodies were detected in fetuses from groups inoculated at gestation days 30 and 41 to 43, whereas virus was isolated from fetuses only from groups inoculated at gestation days 41 to 43. When inoculated directly into the uterus, embryonic or fetal infection with these viruses was observed regardless of the preinoculation serologic status of the gilts, indicating that maternal antibody had no effect on embryonic or fetal infections after the virus was in the uterus. Intranasal inoculation of SMEDI C caused embryonic or fetal infections in seronegative gilts but not in gilts that carried specific antibody to SMEDI C at the time of exposure. Antibodies in gilts that were seropositive at time of inoculation probably neutralized the virus before it could reach the uterus and thus prevented embryo or fetal infections.
在一系列实验中，在妊娠第0天至30天期间，以宫内途径给妊娠小母猪接种猪肠道病毒8型（SMEDI A）；在妊娠第30天至41天至43天期间，给妊娠小母猪接种猪肠道病毒1型（SMEDI C）。在妊娠第30天和41天至43天接种的组别的胎儿中检测到抗体，而仅在妊娠第41天至43天接种的组别的胎儿中分离到病毒。当直接接种到子宫内时，无论小母猪接种前的血清学状态如何，均观察到这些病毒引起胚胎或胎儿感染，这表明在病毒进入子宫后，母源抗体对胚胎或胎儿感染没有影响。鼻内接种SMEDI C可导致血清阴性小母猪发生胚胎或胎儿感染，但在暴露时携带针对SMEDI C的特异性抗体的小母猪中则不会发生感染。接种时血清呈阳性的小母猪体内的抗体可能在病毒到达子宫之前就将其中和，从而防止了胚胎或胎儿感染。
