Siede W H, Seiffert U B, Bundschuh F, Malluche H H, Schoeppe W
Clin Nephrol. 1980 Jun;13(6):277-81.
Alkaline phosphatase bone isoenzyme activity in serum correlates significantly to micromorphometrically assessed parameters of bone apposition as well as resorption. Though as both processes appear to be coupled in renal osteopathy, bone isoenzyme activity seems to reflect mainly hyperosteoid states. The detection of abnormal findings is impressively better by bone isoenzyme analysis as compared with total alkaline phosphatase activity; pathological values are found even at the initial phase of osteopathy in early renal failure. The determination of alkaline phosphatase bone isoenzyme activity in serum is a sensitive and reliable diagnostic tool in assessing the beginning and degree of metabolic bone disease.
血清中碱性磷酸酶骨同工酶活性与通过微观形态计量学评估的骨沉积及骨吸收参数显著相关。尽管在肾性骨病中这两个过程似乎是相互关联的，但骨同工酶活性似乎主要反映骨样组织增多的状态。与总碱性磷酸酶活性相比，通过骨同工酶分析检测异常结果的效果明显更好；在早期肾衰竭的骨病初始阶段甚至就能发现病理值。测定血清中碱性磷酸酶骨同工酶活性是评估代谢性骨病的起始和程度的一种敏感且可靠的诊断工具。
