Naik R B, Gosling P, Price C P
Br Med J. 1977 May 21;1(6072):1307-10. doi: 10.1136/bmj.1.6072.1307.
Liver, intestinal, and bone alkaline phosphatase isoenzymes were measured using heat stability and L-phenylalanine inhibition techniques in 78 patients on intermittent haemodialysis. Fifty-five patients had abnormalities in one or more of the isoenzymes. Changes in bone and intestinal alkaline phosphatase activities seemed to be related and raised liver isoenzyme activity was associated with the development of liver disease. Abnormal histological and radiological findings were better correlated with bone alkaline phosphatase levels than with total alkaline phosphatase, and serial estimations of bone isoenzyme activity were useful in assessing the response of renal osteodystrophy to treatment with a vitamin D analogue. Serum alkaline phosphatase isoenzyme measurement provides another useful and non-invasive index for monitoring metabolic bone disease in patients with chronic renal failure.
采用热稳定性和L-苯丙氨酸抑制技术，对78例接受间歇性血液透析的患者测定了肝脏、肠道和骨碱性磷酸酶同工酶。55例患者的一种或多种同工酶存在异常。骨和肠道碱性磷酸酶活性的变化似乎相关，而肝脏同工酶活性升高与肝脏疾病的发生有关。组织学和放射学异常结果与骨碱性磷酸酶水平的相关性优于与总碱性磷酸酶的相关性，连续测定骨同工酶活性有助于评估肾性骨营养不良对维生素D类似物治疗的反应。血清碱性磷酸酶同工酶测定为监测慢性肾衰竭患者的代谢性骨病提供了另一种有用的非侵入性指标。
