Asaba H, Rekola S, Bergstrand A, Wasserman H, Bergström J
Clin Nephrol. 1980 Aug;14(2):60-5.
Four patients with rapidly progressive crescentic glomerulonephritis were treated with repeated plasma exchanges, using a disposable plasma filter (PLASMAFLO), combined with immunosuppression and anticoagulation. A definite improvement of renal function was observed in two patients and complete recovery of the severe lung changes of Goodpasture's syndrome was seen in one of them. In another patient rapid progression of renal insufficiency was arrested. One patient with anuria at the start of treatment remained anuric. The filter was capable of removing as large a molecule as IgM, and the plasma concentrations of immunoglobulins and complement factors declined successively after each treatment. Plasma exchange with the filter technique is readily accessible and safe in hands of the hemodialysis staff. Easy availability and simplicity are important advantages over the centrifuge methods, considering that prompt commencement of the treatment is a key issue in success.
4例快速进行性新月体性肾小球肾炎患者接受了重复血浆置换治疗，使用一次性血浆滤器（PLASMAFLO），并联合免疫抑制和抗凝治疗。2例患者肾功能有明显改善，其中1例Goodpasture综合征严重肺部病变完全恢复。另1例患者肾功能不全的快速进展得到阻止。1例治疗开始时无尿的患者仍无尿。该滤器能够清除如IgM这样的大分子，每次治疗后免疫球蛋白和补体因子的血浆浓度相继下降。在血液透析工作人员操作下，采用滤器技术进行血浆置换容易实施且安全。鉴于及时开始治疗是成功的关键问题，与离心法相比，易于获得和操作简便具有重要优势。
