Tamarkin L, Reppert S M, Orloff D J, Klein D C, Yellon S M, Goldman B D
Endocrinology. 1980 Oct;107(4):1061-4. doi: 10.1210/endo-107-4-1061.
The ontogeny of the pineal melatonin rhythm was determined in three rodent species. Pineal glands were obtained either during the day or during the expected peak in melatonin at night. In all species the rhythm was first detected during the second week of life. Investigations of the photic regulation of pineal melatonin revealed that light could inhibit the nocturnal increase in melatonin in all species by the end of the second week of life. These studies indicate that for these species the development of the rhythm in pineal melatonin and the development of the mechanism involved in the photic suppression of the nocturnal increase in melatonin are independent of the role the pineal gland plays in regulating reproductive function in response to changes in environmental lighting.
在三种啮齿动物物种中确定了松果体褪黑素节律的个体发生。松果体在白天或夜间褪黑素预期峰值时获取。在所有物种中，节律在出生后第二周首次被检测到。对松果体褪黑素光调节的研究表明，到出生后第二周结束时，光照可抑制所有物种夜间褪黑素的增加。这些研究表明，对于这些物种而言，松果体褪黑素节律的发育以及参与光抑制夜间褪黑素增加的机制的发育，与松果体在响应环境光照变化调节生殖功能中所起的作用无关。
