Kurl R N, Borthwick N M
J Endocrinol. 1980 Jun;85(3):519-24. doi: 10.1677/joe.0.0850519.
The antioestrogens clomiphene and tamoxifen exhibit both agonistic and antagonistic properties in the rat uterus. The effect of these antioestrogens on RNA polymerase activities in the rat uterus was investigated. Both compounds stimulated an early increase in the activity of endogenous RNA polymerase B similar to that observed after oestradiol treatment. A secondary stimulation of activity of RNA polymerase B was observed after treatment with oestradiol and both antioestrogens. In addition, the activity of endogenous RNA polymerase A was increased initially at 1 h by all three compounds but this activity was maintained at 24 h only by oestradiol.
抗雌激素药物克罗米芬和他莫昔芬在大鼠子宫中表现出激动和拮抗两种特性。研究了这些抗雌激素药物对大鼠子宫中RNA聚合酶活性的影响。两种化合物均刺激内源性RNA聚合酶B的活性早期增加，类似于雌二醇处理后观察到的情况。在用雌二醇和两种抗雌激素药物处理后，观察到RNA聚合酶B活性的二次刺激。此外，所有三种化合物最初在1小时时均使内源性RNA聚合酶A的活性增加，但仅雌二醇能在24小时时维持这种活性。
