Kuroiwa Y, Sugita H, Toyokura Y, Mizoguchi M, Matsuo H, Nonaka Y
J Neurol Sci. 1980 Aug;47(2):231-9. doi: 10.1016/0022-510x(80)90007-6.
A broad spectrum of immunologic parameters was investigated in 13 cases of myotonic muscular dystrophy (MyD), including those for cellular immunity which has attracted little attention in the past. One was a 46-year-old woman having both MyD and a thymoma. This association between MyD and thymoma is probably coincidental without biologic significance. There was no evidence of malignancy in the remaining 12 patients. The delayed cutaneous hypersensitivity reaction to dinitrochlorobenzene was anergic in 3 patients and showed impaired positive reactivity in 3 patients, as compared with no failure of response in normal adults or children with Duchenne muscular dystrophy. A high proportion of patients with MyD displayed positive tuberculin reactions, as did controls. Our case of MyD with a thymoma showed marked lymphocytopenia in peripheral blood, but the number of lymphocytes in peripheral blood in the remaining 12 patients was normal. Uptake of tritiated thymidine by lymphocytes in the presence of phytohemagglutinin was normal. Serum gammaglobulin was reduced in 4 patients with MyD. The mean value of serum immunoglobulin level was decreased only in the class of IgG. A wider derangement of immunologic function may occur in MyD than was previously recognized.
对13例强直性肌营养不良（MyD）患者的一系列免疫参数进行了研究，包括过去很少受到关注的细胞免疫参数。其中1例为46岁女性，同时患有MyD和胸腺瘤。MyD与胸腺瘤之间的这种关联可能是巧合，没有生物学意义。其余12例患者无恶性肿瘤证据。与正常成年人或杜氏肌营养不良儿童无反应失败相比，3例患者对二硝基氯苯的迟发性皮肤过敏反应无反应，3例患者阳性反应受损。MyD患者中有很大比例的人结核菌素反应呈阳性，对照组也是如此。我们的MyD合并胸腺瘤病例外周血淋巴细胞明显减少，但其余12例患者外周血淋巴细胞数量正常。在植物血凝素存在的情况下，淋巴细胞对氚标记胸腺嘧啶核苷的摄取正常。4例MyD患者血清γ球蛋白降低。血清免疫球蛋白水平的平均值仅在IgG类别中降低。MyD可能比以前认识到的存在更广泛的免疫功能紊乱。
