抗肿瘤剂XXXVI：小花天人菊中倍半萜内酯微海菊内酯-A、B和C、微海菊内酯乙酸酯及普列诺林的结构解析
Antitumor agents XXXVI: Structural elucidation of sesquiterpene lactones microhelenins-A, B, and C, microlenin acetate, and plenolin from Helenium microcephalum.
作者信息
Imakura Y, Lee K H, Sims D, Wu R Y, Hall I H, Furukawa H, Itoigawa M, Yonaha K
出版信息
J Pharm Sci. 1980 Sep;69(9):1044-9. doi: 10.1002/jps.2600690916.
PMID:7411405
Abstract
The antitumor sesquiterpene lactones microhelenins-A, B, and C, microlenin acetate, and plenolin were isolated from Helenium microcephalum. The structures and stereochemistry of these lactones were determined by physical methods as well as by chemical transformations and correlations. Microlenin acetate appears to be the first novel dimeric sesquiterpene lactone demonstrated to have significant antileukemic activity.
摘要
从微头堆心菊（Helenium microcephalum）中分离出了具有抗肿瘤作用的倍半萜内酯微堆心菊素A、B和C、微堆心菊素乙酸酯以及堆心菊灵。通过物理方法以及化学转化和关联确定了这些内酯的结构和立体化学。微堆心菊素乙酸酯似乎是首个被证明具有显著抗白血病活性的新型二聚倍半萜内酯。
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