倍半萜内酯。第十五部分。来自洋甘菊（Anthemis nobilis L.）草的具有细胞抑制活性的新型倍半萜内酯
Sesquiterpene lactones. Part XV. New cytostatic active sesquiterpene lactone from herb of Anthemis nobilis L.
作者信息
Grabarczyk H, Drozdz B, Hladoń B, Wojciechowska J
出版信息
Pol J Pharmacol Pharm. 1977 Jul-Aug;29(4):419-23.
PMID:905207
Abstract
From fresh and dried herb (without inflorescences) of Anthemis nobilis L. a new sesquiterpene lactone C20H26O6 was isolated. This compound showed a cytotoxic activity at a level of ED50 HeLa -- 0-56 microgram/ml (1-5 x 10(-6) M), and ED50 KB -- 1.23 microgram/ml (3-5 x 10(-6) M), what qualifies it for further in vivo studies.
摘要
从高贵菊（Anthemis nobilis L.）的新鲜和干燥草药（无花序）中分离出一种新的倍半萜内酯C20H26O6。该化合物在HeLa细胞系中的半数有效剂量（ED50）为0.56微克/毫升（1.5×10⁻⁶ M），在KB细胞系中的ED50为1.23微克/毫升（3.5×10⁻⁶ M），表现出细胞毒性活性，这使其有资格进行进一步的体内研究。
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