Babichev V N, Ozol' L Iu, Peryshkova T A
Probl Endokrinol (Mosk). 1980 Jul-Aug;26(4):55-60.
Determination of estradiol receptors content in the nuclear fraction of the female rats' hypothalamus demonstrated their number to alter during the postnatal development. Numerous nuclear E2-binding sites were revealed in the hypothalamus of 14-day-old female rats. The E2-binding level fell by the 21st day after birth, persisting at this level up to sexual maturity. The nuclear receptor content was maximal at this age period. Estradiol receptors possessed a high degree of affinity to the recepted hormone, and also specificity. Estradiol nuclear receptors were revealed in the brain cortex only in 7-day-old rats.
对雌性大鼠下丘脑核部分中雌二醇受体含量的测定表明，其数量在出生后发育过程中会发生变化。在14日龄雌性大鼠的下丘脑中发现了大量核E2结合位点。出生后第21天，E2结合水平下降，并一直维持在该水平直至性成熟。在此年龄阶段，核受体含量最高。雌二醇受体对所结合的激素具有高度亲和力，且具有特异性。仅在7日龄大鼠的大脑皮层中发现了雌二醇核受体。
