孕酮、雌二醇、睾酮和双氢睾酮：对大鼠条件性味觉厌恶消退率的影响。

Progesterone, estradiol, testosterone and dihydrotestosterone: effects on rate of extinction of a conditioned taste aversion in rats.

作者信息

Chambers K C

出版信息

Physiol Behav. 1980 Jun;24(6):1061-5. doi: 10.1016/0031-9384(80)90048-7.

Abstract

An investigation was made to determine why the prolonged rate of extinction of a conditioned taste aversion induced by testosterone is diminished when the ovarian system is intact. In the first experiment, 36 gonadectomized female rats received injections of progesterone, testosterone propionate (TP), progesterone plus TP, or sesame oil. Progesterone did not reduce the slow extinction rate induced by TP. In a second experiment, 36 gonadectomized female rats received injections of estradiol dipropionate (EP), TP, EP plus TP, or sesame oil. Estradiol dipropionate reduced the effectiveness of TP in prolonging the extinction rate. These same results (the ineffectiveness of progesterone and the effectiveness of EP in blocking TP-induced slow extinction) were also observed in male rats in a third experiment. Dihydrotestosterone, as well as testosterone, has been shown to prolong extinction: hence, in a fourth experiment 30 gonadectomized female rats received injections of EP, TP, dihydrotestosterone propionate (DHTP), EP plus DHTP, or sesame oil. Estradiol dipropionate reduced the DHTP-induced slow extinction. All the above data are consistent with the hypothesis that it is estradiol from the ovaries that diminishes the effect of testosterone on the rate of extinction of a conditioned taste aversion in intact females.

摘要

进行了一项调查，以确定当卵巢系统完好无损时，为何睾酮诱导的条件性味觉厌恶的延长消退率会降低。在第一个实验中，36只去势雌性大鼠接受了孕酮、丙酸睾酮（TP）、孕酮加TP或芝麻油的注射。孕酮并未降低TP诱导的缓慢消退率。在第二个实验中，36只去势雌性大鼠接受了二丙酸雌二醇（EP）、TP、EP加TP或芝麻油的注射。二丙酸雌二醇降低了TP延长消退率的有效性。在第三个实验中，雄性大鼠也观察到了相同的结果（孕酮无效，EP在阻断TP诱导的缓慢消退方面有效）。已证明双氢睾酮以及睾酮会延长消退时间：因此，在第四个实验中，30只去势雌性大鼠接受了EP、TP、丙酸双氢睾酮（DHTP）、EP加DHTP或芝麻油的注射。二丙酸雌二醇降低了DHTP诱导的缓慢消退。上述所有数据均与以下假设一致，即来自卵巢的雌二醇会减弱睾酮对完整雌性动物条件性味觉厌恶消退率的影响。