Fishman J, Tulchinsky D
Science. 1980 Oct 3;210(4465):73-4. doi: 10.1126/science.7414322.
The nonuterotropic natural estrogen 2-hydroxyestrone administered to normal young women results in a prompt and profound suppression of serum prolactin in most of the subjects. With the exception of dopamine, this is the only endogenous material known to strongly inhibit prolactin secretion, and its action suggests that the physiological regulation of prolactin by estrogens in the human is dual in nature, consisting of stimulation by estradiol and inhibition by its catechol estrogen metabolite.
给正常年轻女性施用非子宫促性天然雌激素2-羟雌酮，会使大多数受试者的血清催乳素迅速且显著降低。除多巴胺外，这是已知的唯一能强烈抑制催乳素分泌的内源性物质，其作用表明，雌激素对人类催乳素的生理调节具有双重性质，包括雌二醇的刺激作用及其儿茶酚雌激素代谢产物的抑制作用。
