Holdorff B
Strahlentherapie. 1980 Aug;156(8):530-7.
Delayed cerebral necroses after irradiation are to be divided into hemispheric and midline lesions, as they differ from each other in sesveral aspects. Apart from the symptoms, they are differing in the duration of latency, in the course and prognosis, and also with regard to morphology. Though there is no doubt that radiation tolerance of cerebral midline structures is relatively limited, on biological grounds, evidence of a difference between the tolerated doses could not be given from the existent inhomogeneous radiation data, with the help of the NSD-concept. Radiation planning for the region of the head, nevertheless, carefully should avoid in every case to involve the structures of the cerebral midline.
照射后迟发性脑坏死可分为半球性和中线性病变,因为它们在几个方面彼此不同。除症状外,它们在潜伏期、病程和预后方面存在差异,在形态学方面也有所不同。尽管毫无疑问,脑中线结构的放射耐受性相对有限,但基于生物学原因,根据现有的不均匀放射数据,借助NSD概念,无法给出耐受剂量之间存在差异的证据。然而,头部区域的放射治疗计划在任何情况下都应谨慎避免累及脑中线结构。