Bach D, Hesse A, Vahlensieck W
Urologe A. 1980 Jul;19(4):220-5.
The citric acid excretion and concentration in 24 hours urine was measured in 70 stone-formers and 16 normal subjects (controls) on normal food intake followed by 9 days on a standard diet. On days 9 and 10 on the standard diet urine was collected in 3 hours portions and citric acid and calcium was measured. From day 7 to day 10 on standard diet we found only a slight change in the 24-hour excretion of citric acid ("steady state"). The citric acid excretion and concentration is significantly lower in stone-formers than in healthy controls. In both groups there is a sinusoid rhythm in citric acid excretion and concentration throughout the 24 hour period. The calcium concentration is at its maximum when the citric acid concentration is at its minimum.
对70名结石形成者和16名正常受试者(对照组)进行了研究,在正常饮食摄入情况下,随后进行9天的标准饮食,测量其24小时尿液中的柠檬酸排泄量和浓度。在标准饮食的第9天和第10天,每3小时收集一次尿液,测量柠檬酸和钙的含量。从标准饮食的第7天到第10天,我们发现24小时柠檬酸排泄量仅有轻微变化(“稳定状态”)。结石形成者的柠檬酸排泄量和浓度显著低于健康对照组。在两组中,24小时内柠檬酸排泄量和浓度均存在正弦节律。当柠檬酸浓度最低时,钙浓度最高。