Augustin H J, Huland H
Z Urol Nephrol. 1980;73(7):507-15.
Renal and intrarenal hemodynamics were studied over a period of 6 months in the hydronephrotic dog kidney after unilateral complete ligation of the ureter. Already 7 hours after ligation renal blood flow was reduced. The intrarenal blood flow distribution changed with a massive reduction in cortical and only slight decrease in medullary perfusion. This alteration of intrarenal blood flow resulted in a change of the compartment fractions. Dopamine, applied intravenously in a dose of 4 micrograms kg-1 min-1, induced a vasodiilation of the obstructed kidney during the whole period of investigation. Especially the reduced cortical blood flow could be improved by the application of dopamine.
在单侧输尿管完全结扎后的肾盂积水犬肾中，对肾和肾内血流动力学进行了为期6个月的研究。结扎后仅7小时，肾血流量就减少了。肾内血流分布发生变化，皮质灌注大量减少，而髓质灌注仅略有下降。肾内血流的这种改变导致了各部分比例的变化。以4微克/千克·分钟的剂量静脉注射多巴胺，在整个研究期间可使梗阻肾血管舒张。尤其是应用多巴胺可改善减少的皮质血流量。
